Amonute — known publicly as Pocahontas, a nickname meaning "playful one" or "ill-behaved child" — was the favourite daughter of Chief Powhatan, the paramount chief of an approximately 30-tribe confederacy in what is now Virginia. She was born around 1596. When English settlers arrived at Jamestown in May 1607 under Captain John Smith, Pocahontas was approximately 10–12 years old. Smith was 27. Their relationship was complex — she served as an informal ambassador and interpreter between the Powhatan Confederacy and the colony, bringing food, carrying messages, and facilitating fragile early diplomacy. The famous story that she saved Smith from execution by placing her head over his — which Smith himself told — is now understood by historians as likely a ritual of adoption or incorporation ceremony in which Pocahontas's role was symbolic and prearranged, not a spontaneous rescue from actual death.

Smith left Virginia in 1609 due to injury and Pocahontas was told he had died. In 1613, aged approximately 17, Pocahontas was lured aboard an English ship and held hostage to pressure Chief Powhatan to release English prisoners and return stolen weapons. During her captivity, she converted to Christianity, took the name Rebecca, and was introduced to tobacco planter John Rolfe. In 1614 she married him — whether this was fully voluntary given her captive status is debated.

In 1616, she traveled to England as a living symbol of England's "civilising" mission in Virginia — meeting King James I and being presented at court. She was celebrated but also displayed as an exotic curiosity. She became ill. In March 1617, boarding a ship to return home at last, she was taken off at Gravesend, too sick to travel. She died there, aged approximately 21, probably of pneumonia or tuberculosis. She never saw her homeland, tribe or family again.