| Title | Role | Notes | |
| 2015 | 1001 Inventions and the World of Ibn Al-Haytham | Grandfather | film lead & final film role | 
| 2013 | A Castle in Italy | Himself | |
| 2013 | Rock the Casbah | Moulay Hassan | |
| 2009 | The Traveller | Older Hassan | Commonly known as Al Mosafer | 
| 2009 | J'ai oublié de te dire[99] | Jaume | Also known as I Forgot to Tell You | 
| 2008 | 10,000 BC | Narrator | Voice | 
| 2008 | Hassan & Marcus | Hassan / Morcus | Also known as Hassan wa Morcus | 
| 2006 | Fuoco su di me | Principe Nicola | |
| 2006 | One Night with the King | Prince Memucan | |
| 2006 | The Crown Prince | Hans Canon | |
| 2005 | The Chronicles of Narnia: The Lion, the Witch and the Wardrobe (Italian vers.) | Aslan (voice) | Italian dub | 
| 2004 | Hidalgo | Sheikh Riyadh | |
| 2003 | Monsieur Ibrahim | Monsieur Ibrahim | César Award for Best Actor | 
| 2001 | Censor | ||
| 2001 | The Parole Officer | Victor | |
| 1999 | The 13th Warrior | Melchisideck | |
| 1997 | Heaven Before I Die | Kahlil Gibran | |
| 1996 | Lebanon...Imprisoned Splendour | Himself | Documentary | 
| 1993 | Laughter, Games, Seriousness and Love | Adham's father | Also known as Dehk we le'b we gad we hob | 
| 1992 | 588 rue paradis | Hagop | Also known as Mother | 
| 1992 | Beyond Justice | Emir Beni-Zair | |
| 1992 | Tengoku no Taizai | Tsai Mang Hua | |
| 1991 | War in the Land of Egypt | Mayor Abdel Razek El-Shershaby | Also known as El Mowaten Masri and An Egyptian Citizen | 
| 1991 | Mayrig | Hagop | |
| 1990 | Mountains of the Moon | Sultan | Uncredited | 
| 1990 | Viaggio d'amore | Rico | |
| 1990 | The Rainbow Thief | Dima | |
| 1989 | Al-aragoz [citation needed] | Mohamed Gad El Kareem | Also known as The Puppeteer | 
| 1988 | The Possessed | Stepan | Also known as Les Possédés | 
| 1988 | Les Pyramides bleues [fr] [97] | Alex | Also known as The Novice | 
| 1988 | Keys to Freedom | Jonathan | |
| 1988 | Mysteries of Egypt | Grandfather | Documentary | 
| 1987 | Grand Larceny | Rashid Saud | |
| 1984 | Top Secret! | Agent Cedric | |
| 1983 | Ayoub | Abdelhamid El-Sokkary | |
| 1981 | Green Ice | Meno Argenti | |
| 1981 | Inchon | Indian officer | Cameo; uncredited | 
| 1980 | S*H*E [96] | Baron Cesare Magnasco | Also known as S*H*E: Security Hazards Expert | 
| 1980 | The Baltimore Bullet | The Deacon | |
| 1980 | Oh! Heavenly Dog | Malcolm Bart | |
| 1979 | Ashanti: Land of No Mercy | Prince Hassan | |
| 1979 | Bloodline | Ivo Palazzi | |
| 1976 | Ace Up My Sleeve | Andre Ferren | Also known as Crime and Passion | 
| 1976 | The Pink Panther Strikes Again | Egyptian Assassin | Cameo; uncredited | 
| 1975 | Funny Lady | Nicky Arnstein | |
| 1974 | The Tamarind Seed | Feodor Sverdlov | |
| 1974 | Juggernaut | Captain Alex Brunel | |
| 1973 | The Mysterious Island | Captain Nemo | |
| 1972 | Le Droit d'aimer | Pierre | |
| 1971 | The Last Valley | Vogel | |
| 1971 | The Horsemen | Uraz | |
| 1971 | The Burglars | Abel Zacharia | Simultaneously shot in French as Le Casse with same cast | 
| 1969 | Mackenna's Gold | John Colorado | |
| 1969 | The Appointment | Frenderico Fendi | |
| 1969 | Che! | Che Guevara | |
| 1969 | Trois hommes sur un cheval | Un turfiste | Uncredited | 
| 1968 | Funny Girl | Nicky Arnstein | |
| 1968 | Mayerling | Archduke Rudolf | |
| 1967 | The Night of the Generals | Major Grau | |
| 1967 | More Than a Miracle | Prince Rodrigo Fernandez | |
| 1965 | Genghis Khan | Genghis Khan | |
| 1965 | Marco the Magnificent | Sheik Alla Hou, 'The Desert Wind' | |
| 1965 | Doctor Zhivago | Dr. Yuri Andreyevich Zhivago | Golden Globe Award for Best Actor – Motion Picture Drama | 
| 1965 | The Mamelukes | Ahmed | Participated in Thessaloniki International Film Festival | 
| 1964 | The Fall of the Roman Empire | Sohamus | |
| 1964 | Behold a Pale Horse | Francisco | |
| 1964 | The Yellow Rolls-Royce | Davich | |
| 1962 | Lawrence of Arabia | Sherif Ali ibn el Kharish | - Golden Globe Award for Best Supporting Actor – Motion Picture - Golden Globe Award for New Star of the Year – Actor - Nominated – Academy Award for Best Supporting Actor | 
| 1961 | Gharam el assiad | Essam Murad | Also known as Masters Love | 
| 1961 | The Beginning and the End | Hassanien | Also known as Bidaya wa Nihaya | 
| 1961 | A Rumor of Love | Hussein | Also known as Esha'a hob | 
| 1961 | The River of Love | Khalid | Also known as Nahr al-Hob | 
| 1961 | My Only Love | Captain Adel | Also known as Hobi al-Wahid | 
| 1961 | There is a Man in our House [95] | Ibrahim | Also known as Fi Baytouna Ragoul | 
| 1960 | We Are the Students | Adel | Also known as Ehna el talamiza | 
| 1960 | Love Sickness | Hasan | Also known as Lawet el hub | 
| 1959 | Struggle on the Nile [95] | Muhassab | Also known as Siraa fil Nil | 
| 1959 | Lady of the Palace | Adel | Also known as Sayyidat al-Qasr | 
| 1959 | For a Woman | Shokri | Also known as Min ajal emraa For a Woman | 
| 1959 | Appointment with the Unknown | Madgi | Also known as An Maweed maa maghoul | 
| 1959 | Scandel in Zamalek | Ahmed | Also known as Fadiha fil Zamalek | 
| 1958 | Goha | Goha | Credited as Omar Cherif | 
| 1958 | Beach of Secrets | Mamdoh | Also known as Shatie el asrar | 
| 1958 | My Lover's Fault | Salah | Also known as Ghaltet habibi | 
| 1957 | Sleepless | Aziz | Also known as La Anam and No Tomorrow | 
| 1957 | Land of Peace | Ahmed | Also known as Ard al-Salam | 
| 1956 | La Châtelaine du Liban | Mokrir | Also known as The Lebanese Mission | 
| 1956 | Struggle in the Pier | Ragab | Also known as A Fight Within the Port, Sira` Fi al-Mina | 
| 1955 | Our Beautiful Days | Ahmed | Also known as Ayyamna al-Holwa | 
| 1954 | Devil of the Sahara[94] | Essam | Also known as Shaytan al-Sahara | 
| 1954 | The Blazing Sun | Ahmed | Also known as Struggle in the Valley and Sira` Fi al-Wadi |